![]() The key therapeutic use for flumazenil is the management of diazepam overdosed and/or setback of benzodiazepine symptoms following anesthesia (4-6) A possible side effect is an anxiogenic action. Flumazenil competitively prevents benzodiazepine-recognition action at the GABA/benzodiazepine receptor cluster, thus preventing the actions of benzodiazepines (3). Keywords: Flumazenil, Diazepam, Attention bias test, Open field test, Chicks The neurobehavioral effects of flumazenil in chicksĭepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, 0000-0003-1618-0678 corresponding 0000-0003-4301-1095 These findings indicate that the impact of flumazenil is indicative of the characteristics of partial agonists when given on its own and antagonist when given after diazepam according to the neurobehavioral tests. Flumazenil demonstrated fairly unexpectedly a depressant effect in the open field test and sedative and anxiolytic bias attention test in the chick’s model. Flumazenil at 0.1 and 0.2 mg/kg have antagonistic effects in chicks sedated with diazepam at 10mg/kg. Flumazenil at 0.1, 0.2 and 0.4 mg/kg cause mild sedation in chicks. Flumazenil at 0.04 and 0.08 mg/kg diminished the locomotors activity, prolonged the period of tonic immobility and have anxiolytic action in chicks. The Median effective dose of flumazenil injected chicks was 0.114 mg/kg i.p. The objective of this study was to scrutinize the neurobehavioral reaction as well as sedative and anxiolytic actions of flumazenil in chick’s model. Its administration in humans and some animal’s model is connected with nervousness, anxiety responses, or seizures attacks. ![]() ![]() ![]() Flumazenil is choosy and competitive GABA receptor blocker that serves as an antidote to benzodiazepines overdose. ![]()
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